TUBB3 and cancer: Although these distinct drug-induced mt organization regulatory events may suggest a connection between β-tubulin isotypes such as TUBB3 and FOXO transcription factors, very little is known about the systemic relation of these factors and their collective function as interacting elements in the regulation of the response of cancers to chemotherapeutic drugs and the malignant progression of tumors caused by MDR that often leads to cancer recurrence.