TUBB3 and in situ carcinoma: The subcutaneous tumor mass (in grams; g) of the control group was approximately 1.98 g (n = 2; 8 isolated tumor xenografts of A549-PacR/5-FU) and 0.89 g (n = 2; 8 isolated tumor xenografts of PC-3-PacR/CIS), whereas the mass of the tumor induced by TUBB3 siRNA-transfected cells was inhibited by 19% (p < 0.011) and 32% (p < 0.005) with tumor masses of approximately 1.62 g (n = 2; 8 isolated tumor xenografts of A549-PacR/5-FU) and 0.61 g (n = 3; 12 isolated tumor xenografts of PC-3-PacR/CIS) (Supplementary Figure 8), respectively.