A gene expression analysis showed that both TUBB3 and FOXO3a mRNA levels are relatively lower in non-cancer RWPE-1 prostate cells, L132 and MRC-5 lung cells, and HEK293 and HUVEC cells whereas their levels are higher in drug-sensitive cancer PC-3 prostate cells and H292 and A549 lung cells. The gene discussed is FOXO3; the disease is cancer.