Additionally, many pluripotency and EC associated genes, like SOX2, ZIC3, ZFP42, LIN28, SALL4 and PRDM14 were upregulated without correlating to changes in their 5mC status [7], while seminoma markers SOX17, cKIT, PRDM1 and PRAME were downregulated. This evidence concerns the gene SOX2 and seminoma.