CA4 and neoplasm: The Kaplane-Meier survival curves showed that the median survival time of U87-MG tumor-bearing nude mice treated with NGR-SSL-CA4 (25 days) was significantly longer than that of mice treated with 5 % glucose injection (16.5 days, p < 0.01), SSL-CA4 (20.5 days, p < 0.01) and free CA4 (19.0 days, p < 0.01), as shown in Figure 7A.