TACSTD2 and Familial prostate cancer: In summary, while extracellular TROP2 overexpression had previously been reported to enhance prostate cancer cell migration and metastatic ability [35] and to correlate with prostate cancer aggressiveness [13], results of the present study provide the first demonstration that high membrane TROP2 expression characterizes different cell subpopulations in androgen-sensitive and androgen-independent prostate cancer cells.