In PC-9 and NCI-H1975 cells, Gefitinib alone can inhibit the EGFR signal pathway; however, when PA-MSHA was used in combination with Gefitinib, EGFR inhibition was observed in all three NSCLC cell lines, both in vitro and in vivo. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.