PRKN and neoplasm: In this regard, PINK1- or Parkin-depleted Ras-transformed cells also displayed decreased anoikis resistance and anchorage-independent growth (Figure 7, Supplementary Figure S14), while detachment-induced autophagy in general appeared to be unaffected by PINK1 knockdown (Supplementary Figure S12), which suggests that mitophagy is critical for anoikis resistance and potentially tumour formation.