STK38 and pancreatic adenocarcinoma: To investigate whether STK38 also promotes anchorage-independent growth of human cancer cells carrying endogenous activating mutations of Ras, we depleted STK38 in HCT116 (colorectal carcinoma cell line expressing KRasG13D), Panc1 (pancreatic adenocarcinoma cell line carrying KRasG12D), H1299 (lung carcinoma cell line expressing NRasQ61K), and T24 cells (urinary bladder carcinoma cell line carrying HRasG12V) (Figure 2).