In the current study, we used three lymphoma cell lines with distinct genetic characteristics, WSU-FSCCL (follicular small cleaved cell lymphoma; t(14;18) BCL-2 and t(8;11) c-myc rearrangements), WSU-DLCL2 (diffuse large cell lymphoma; t(14;18) BCL-2 rearrangement) and WSU-WM (Waldenstrom's macroglobulinemia; t(8;14) c-MYC rearrangement), to investigate the mechanism of action of PNT2258 and its role as a DNAi. The gene discussed is BCL2; the disease is Waldenstrom macroglobulinemia.