In spite of the fact that the newly found missense type mutation resulting from c.538 A > C in exon 7 and the serine deletion of a serine-rich domain in exon 11 of ALPK1 was not specific to colorectal and lung cancers, it would be worthwhile to investigate the relevance between these variants of ALPK1 and the evolution of the variety of cancers in larger ethnic cohorts. This evidence concerns the gene ALPK1 and cancer.