Previously, we examined gene induction by a non-steroidal compound/selective activator of GR called Compound A. Compound A, in contrast to glucocorticoids, did not induce KLK6 expression (data not shown), which may correlate with both general inability of Compound A to induce activation of GR target genes (Compound A is known to shift GR signaling towards gene transrepression) and its inability to cause skin atrophy [37–39]. Here, KLK6 is linked to skin atrophy.