With pathway analysis using the DAVID functional annotation tool (http://david.abcc.ncifcrf.gov/tools.jsp), FOXC2 was found to be correlated to cancer-associated pathways, including the TGF-b [32], Notch [33], ERK and Wnt signaling pathways [34–35] (Supplementary Figure S3A). This evidence concerns the gene FOXC2 and cancer.