As shown in Figure 4A, the HDAC8 promoter regions (positions −168 to +30) were pulled down by an anti-AHR polyclonal antibody in SK-Hep1 hepatoma cell lines transfected with AHR. In contrast, the HDAC8 promoter region was not pulled down if XRE was deleted (Figure 4A). This evidence concerns the gene HDAC8 and hepatocellular carcinoma.