As shown in Figure 4A, the HDAC8 promoter regions (positions −168 to +30) were pulled down by an anti-AHR polyclonal antibody in SK-Hep1 hepatoma cell lines transfected with AHR. In contrast, the HDAC8 promoter region was not pulled down if XRE was deleted (Figure 4A). The gene discussed is AHR; the disease is hepatocellular carcinoma.