HDAC8 and hepatocellular carcinoma: Analyses of seven hepatoma cell lines (Hep G2, Hep 3B, SK-Hep1, Huh 7, PLC/PRF/5, HA22T, and HCC36) revealed that AHR and HDAC8 were highly expressed in all of the hepatoma cell lines as compared with expression levels in normal hepatocytes (Chang normal liver cells, CNL; Figure 3A).