Analysis of the expression patterns of HDAC8 in various tissue samples first showed that HDAC8 mRNA expression in HCC liver samples was significantly upregulated as compared with that in non-HCC patients (Figure 1B; p = 0.0008, one-way ANOVA), while the expression pattern of HDAC8 in HCC samples varied greatly. The gene discussed is HDAC8; the disease is hepatocellular carcinoma.