While PD-L1 expression on TIMCs has been associated with OS and an improved response to the checkpoint inhibitors in mUC28, 29, 30, 31, we also analyzed the association between PD-L1 expression on tumor cells and APOBEC expression, as it may provide insight about how the expression of these two proteins within the same tumor affect each other. The gene discussed is CD274; the disease is neoplasm.