VHL and glioblastoma: 126 demonstrated the utility of miRNA sponges in a glioma cell line and orthotopic mouse model, using an miRNA sponge to inhibit miR‐23b, which functions as an oncogene in GBM. Knockdown of miR‐23b led to a significant reduction in tumor malignancy accompanied by downregulation of HIF1α, β‐catenin, MMP2, MMP9, VEGF, and ZEB1, as well as increased expression of VHL and E‐cadherin. This was able to reduce angiogenesis, migration, and invasion of the GBM cells, thereby inhibiting cancer progression 126.