BAX and glioblastoma: 89 determined that overexpression of miR‐21 significantly inhibited the effect of TMZ on apoptosis, which was mediated through downregulation of proapoptotic proteins Bax and caspase‐3 as well as upregulation of antiapoptotic protein Bcl‐2. Moreover, numerous other studies have investigated the impact of miR‐21 on drug resistance in GBM, finding that inhibiting miR‐21 can enhance the chemosensitivity of human GBM cells to TMZ, paclitaxel, sunitinib, doxorubicin, and VM‐26 39, 90, 91, 92, 93, 94.