HIF1A and cancer: 66 found that miRNAs can also regulate GBM growth through maintenance of tumor stem cells and stem cell niches. Inhibition of miR‐148a and miR‐31 using antisense oligonucleotides was able to reduce cancer cell proliferation, deplete stem cells, and normalize tumor vasculature. These effects were mediated in part through miR‐148a and miR‐31 repression of factor‐inhibiting hypoxia‐inducible factor 1 (FIH1), which can influence angiogenesis and tumor stemness through HIF1α and Notch signaling 66.