Importantly, the administration of anti-ADM antibodies prevents the hyperdynamic response [27] and seems beneficial to survival [32, 33], while exogenous ADM prevents and reverses hypodynamic circulation and pulmonary hypertension, and reduces endothelial hyperpermeability in experimental models of septic shock [4, 5, 30, 34], suggesting possibilities for therapeutic intervention. Here, ADM is linked to pulmonary arterial hypertension.