Studies on AML and ALL suggested that 100 kb region flanking rs55705857 contains 5 tissue-specific MYC enhancers and, despite being 1.9 Mb apart from MYC gene, interacts with SWI/SNF chromatin remodeling complex subunit Brg1 (in AML) or transcription factor Tal1 (in ALL)17, 18, 19. Here, SMARCA1 is linked to acute lymphoblastic leukemia.