IDH2 and astrocytoma (excluding glioblastoma): On the other hand, the picture was less clear with astrocytomas: Both histopathologic and molecular classification of IDH-mutant grade-II astrocytomas revealed a trend toward younger age of patients with A/G genotype, compared to those with A/A genotype; however, the difference did not reach the significance level of p < 0.05 (p = 0.22, Kruskall-Wallis test).