Along these lines, Kucharzewska et al. [64] showed that EVs derived from glioblastoma cells grown under hypoxic conditions were potent inducers of angiogenesis in vitro through phenotypic modulation of endothelial cells: glioblastoma-derived hypoxic EVs induced endothelial cells to secrete several potent growth factors and cytokines and to stimulate the PI3K/AKT signaling pathway. This evidence concerns the gene AKT1 and glioblastoma.