Also, NGFR was highly expressed in a number of cancers, including the cancer initiating cells of melanoma (Boiko et al., 2010), squamous cell carcinomas (Murillo-Sauca et al., 2014), osteosarcoma (Tian et al., 2014), brain cancer (Biagiotti et al., 2006), breast cancer (Kim et al., 2012), and neuroblastoma (Biagiotti et al., 2006). This evidence concerns the gene NGFR and osteosarcoma.