TP53 and cancer: Together with the aforementioned studies (Boiko et al., 2010; Tomellini et al., 2014), our findings also suggest that NGFR might play a role in maintaining the renewal and proliferating capabilities of stem cells or cancer stem cells by inactivating p53, as p53 has been shown to be crucial for stem cell differentiation and apoptosis (Krizhanovsky and Lowe, 2009) and to be a major roadblock for these stem cells to renew and proliferate (Cicalese et al., 2009; Hong et al., 2009; Kawamura et al., 2009; Marion et al., 2009; Utikal et al., 2009).