Although MDM2 and MDMX have been shown to play a role in suppressing p53 in these cancers (Gembarska et al., 2012; Lam et al., 2010; Slack et al., 2005; Wade et al., 2013), it is highly likely that NGFR might also contribute to the reason why these cancers harbor wt p53. The gene discussed is MDM2; the disease is cancer.