But, this result does not affect our conclusion that negation of p53 function is one of the oncogenic functions of NGFR, as it is strongly supported by the evidence that knockdown of NGFR leads to activation of the p53 pathway in H460, HepG2, SK-N-SH, HCT116 p53+/+ and melanoma SK-MEL cells (Figure 3B–D). The gene discussed is NGFR; the disease is melanoma.