NGFR and cancer: In contrast to our findings and the oncogenic role as described above, NGFR has also been shown to exert a tumor suppressive function by repressing tumor growth in several cancers (Molloy et al., 2011), which has been largely attributed to its receptor activity (Barker, 2004; Bredesen and Rabizadeh, 1997; Carter et al., 1996; El Yazidi-Belkoura et al., 2003; Khursigara et al., 2001; Nykjaer et al., 2004; Tomellini et al., 2014).