MBP and myeloid sarcoma: Their proteolytic substrates include myelin basic protein, components of the blood–brain barrier (BBB), and neural/glial antigen 2 (NG2), important for proper remyelinisation in the CNS, giving them a potential important role in both the pathogenesis of MS as well as in the development of new treatments for MS (Chandler et al., 1995; Larsen et al., 2003; Ram et al., 2006).