Although the aberrant cytoplasmic localization of HNRNPA1 has already been observed in CRC tissue [10], subcellular distribution analyses of SRSF3 and SRSF 5–7 in primary cancer cells are rare in the literature, and no studies further describe the extranuclear fractions (cytosol/microsome vs. membrane/organelle). This evidence concerns the gene SRSF3 and colorectal carcinoma.