We detected aberrantly upregulated proteins in the extranuclear fractions in both types of cancer cells and noted that the major distribution patterns of proteins in the extranuclear fractions differ based on the SF type [HNRNPA1 and SRSF6 (cytosol/microsome) vs. SRSF1, 3, 5, and 7 (membrane/organelle)] rather than by cancer type (GC vs. CRC). This evidence concerns the gene SRSF6 and cancer.