We aimed to: (1) identify the translational and transcriptional profiles of five SRSFs (SRSF1, SRSF3, SRSF5, SRSF6, and SRSF7) and HNRNPA1 in GC; and (2) compare the detection accuracy (DA) among the SFs and the currently used tumor marker carcinoembryonic antigen (CEA) [12] and determine specific features in these parameters in GC and CRC. Here, SRSF5 is linked to colorectal carcinoma.