Kulis and co-workers41 reported no differential methylation levels in the SETD2 gene body and promoter regions (15 and 9 CpG probes), respectively, between unmutated or mutated CLL or major cytogenetic subtypes and SETD2 mRNA expression was not correlated with gene methylation status (doi:10.1038/ng.2443: Supplementary Tables S5 and S11).41 Preliminary analysis of our own unpublished Illumina 450 K methylation array data also demonstrated no differences between mutated and unmutated CLL for these probes (Supplementary Figure S6). This evidence concerns the gene SETD2 and B-cell chronic lymphocytic leukemia.