SETD2 and B-cell chronic lymphocytic leukemia: None of these SETD2 mutations (Table 2) are annotated in COSMIC.27 During the preparation of this manuscript, a study performed by Puente et al.28 in 506 CLL patients also described both SETD2 mutations (0.8% of cases) and deletions in 3p (2% of cases) whose MDR encompassed SETD2 while Landau et al.23 identified SETD2 mutations in 8/538 (1.5%) cases.