KMT2A and acute lymphoblastic leukemia: SETD2 genomic abnormalities are associated with decreased H3K36me3 levels, a distinctive DNA methylation signature6 and chemoresistance in paediatric acute lymphoblastic leukaemia.39 In MLL-rearranged cells from acute leukaemic patients, Setd2 knockdown is implicated in disease initiation and progression by promoting the self-renewal capacity of leukaemic stem cells.