ING3 and neoplasm: The 7q31 region contains four candidate tumor suppressor genes, CAV1, CAVal-2, ST7, and ING3. Because mutations in the PHD domain of ING3 are also reported in the genomes of various cancers (Cys-376 (frameshift), D380H, and H387P (33)), we decided to investigate the molecular mechanisms that regulate the association of ING3 with histone post-translational modifications.