Our data show that GABA supplementation had strong cancer preventive effects on pancreatitis-associated PDAC by decreasing cAMP and the pro-inflammatory cytokine interleukin 6 (IL-6), resulting in the simultaneous inhibition of multiple signaling pathways that stimulate the proliferation, progression and metastatic potential of differentiated PDAC cells and increase the self-renewal, clonogenicity and tumorigenicity of cancer stem cells of PDAC. Here, IL6 is linked to pancreatitis.