NOTCH1 and breast cancer: High Notch1 levels have been linked to poor prognosis in breast cancer [5], where Notch1 has been shown to induce epithelial-to-mesenchymal transition (EMT) [6, 7], upregulate extracellular matrix metalloproteinases [8], and induce a switch to glycolytic metabolism [9], contributing to both tumor initiation and progression.