PTEN and neoplasm: We have previously identified that the functional upregulation of secreted-MMP7, a transcriptional target of WP in TNBC is associated with the loss of PTEN [24], a tumor suppressor gene whose loss has been found to be the most common first event associated with basal-like subtype [53] and this PI3K-AKT pathway activating event due to a deletion/mutation/loss of PTEN frequently (35%) occurs in TNBC [54].