LTBP2 and metastatic malignant neoplasm in the lymph nodes: In multivariate analysis, high LTBP2 expression (HR, 3.904, 95% CI: 2.253–6.766; P < 0.001) and presence of lymph node metastasis (HR, 2.701, 95% CI: 1.243–5.867; P = 0.012) remain significantly associated with poor overall survival (Table 3).