EGFR and lung cancer: Lung cancer incidence among female smokers in Taiwan was approximately 4% (2.3%–5.2%) in 1974.[10,11] The cancer types were predominantly adenocarcinoma, often with epidermal growth factor receptor (EGFR) mutations, and which responded to treatment with tyrosine-kinase inhibitors.[8,12] Lung cancer among female nonsmokers may be regarded as a different disease entity and therefore, etiology other than smoking needs to be investigated.