IL6 and rheumatoid arthritis: No related information was provided in the other 9 studies.[24–26,30,31,33–36] Among the 15 studies on the association of the IL-6 -174G/C variants with RA risk, 10 study groups were in HWE,[28–32,34–38] and the other 5 study groups were found to have a significant departure from HWE.[24–27,33]