FTO is expressed in the hypothalamus and modulates food intake and obesity, which is closely linked to insulin resistance.[43] Therefore, the results of our present study confirm that the genomic loci related to secretion tend to predispose lean Chinese Han individuals to T2D, whereas the insulin sensitivity-related genomic loci showed stronger association with obese T2D. Here, FTO is linked to obesity due to melanocortin 4 receptor deficiency.