The T2D risk alleles of genetic variants in BCL11A, PPARG, WFS1, CDKN2BAS, HHEX, KCNQ1, and CENTD2 were related to greater β-cell dysfunction (HOMA-B, insulinogenic index), and the T2D risk allele of the genetic variant in PPARG was related to better insulin sensitivity (ISIm). The gene discussed is HHEX; the disease is type 2 diabetes mellitus.