Notably, T2D patients with a higher T2D GRS showed greater β-cell dysfunction (HOMA-B: −0.0159 [0.0047], P = 7.76 × 10−4; insulinogenic index: −0.0294 [0.0087], P = 6.98 × 10−4) and better insulin sensitivity (0.0107 [0.0036], P = 2.91 × 10−3). This evidence concerns the gene INS and type 2 diabetes mellitus.