Our previous study in a Chinese Han population confirmed the associations of T2D with GWAS-validated SNPs in or near WFS1, CDKAL1, CDKN2A/2B, CDC123/CAMK1D, HHEX, TCF7L2, KCNQ1, and MTNR1B, all of which were essential in β-cell function.[9] However, many genetic variants have been revealed by GWAS in Caucasians that could not be replicated in Chinese Han or other East Asian populations, partly due to the heterogeneity of T2D. Here, HHEX is linked to type 2 diabetes mellitus.