A similar pattern can be found for other drugs: Abuaf et al[23] (2008) found that CD203c seems to have more sensitivity for the detection of amoxicillin-activated basophils, but CD63 had more sensitivity in patients with anaphylaxis to muscle relaxants.[24] Differences have also been described for allergens: CD203c is a better marker for latex allergy[40]; CD63 is more specific but CD203c more sensitive for bee or wasp allergy[32]; and both can be reliable markers for cat allergy diagnosis.[29] These studies suggest that different basophil activation pathways exist depending on the culprit. The gene discussed is CD63; the disease is anaphylaxis.