Their consumption is increasing, particularly for certain derivatives like ciprofloxacin (CIP) and more recently moxifloxacin (MOX).[2] This has led to an increase in allergic reactions and they are now the non-betalactam antibiotics most frequently involved in allergic drug reactions.[3–6] Most of these reactions are thought to be IgE-mediated, being anaphylaxis and urticaria the most frequently reported,[7–12] but since the introduction of MOX, more severe reactions, such as anaphylactic shock, have been reported.[8,13] This FQ has been shown to be involved in >60% of severe reactions.[11]. Here, IGHE is linked to anaphylaxis.