On this issue, a previous meta-analysis was insufficient to support the prognostic value of HER-2 overexpression, and the most recently published meta-analysis of 8 studies failed to include several studies that could be pooled into a meta-analysis, especially those that correlated overexpression of HER-2 in osteosarcoma with a favorable prognosis. Here, ERBB2 is linked to osteosarcoma.