Using our previously published transcriptome data [41], we found that the inter-patient variation in HO-1 mRNA levels in metastases was large and CRPC cases showed an inverse correlation to AR mRNA levels (Rs = -0.41, p = 0.022, n = 31) while being positively correlated to mRNA levels for CD68 (Rs = 0.70, p = 0.000013, n = 31) and CD163 (Rs = 0.53, p = 0.002, n = 31), but not iNOS (Rs = -0.17, p = 0.38, n = 31), indicating HO-1 expression in M2 macrophages in human PC bone metastases with less AR activity. The gene discussed is CD68; the disease is pachyonychia congenita.