CD4 and disseminated candidiasis: Neutrophil activation requires IL-17 signaling and recent evidence has suggested that innate lymphoid cells (ILC) represent an important source of IL-17 to support neutrophil activation in the absence of Th17 CD4 T cells [55], which may help explain why disseminated candidiasis remains uncommon even in HIV-infected patients with severe CD4 T cell depletion.