CD4 and HIV infectious disease: As shown in Fig 6C, while the C. albicans-specific CD4 T cells were readily detectable at fairly high levels early after HIV infection, they were lost or greatly reduced at late stage of HIV infection (p = 0.01); in contrast, the CMV-specific CD4 T cells were well maintained at comparable levels in both early and late stage of HIV infection from the same HIV-infected individuals (Fig 6C and 6D).