CALR and bipolar disorder: Intriguingly, HSP90B1 (Drosophila Gp93) and CALR (Drosophila Crc), homologues of molecular chaperones upregulated when Ets96B was knocked down in the nervous system, are not properly induced during increased endoplasmic reticulum (ER) stress in lymphoblastoid cells recovered from bipolar disorder patients [18].