MACC1 promoted GC cell proliferation and invasion by inducing the epithelial-mesenchymal transition (EMT) through activation of HGF/ c-Met signaling pathway[8], and induced VM formation of GC by HGF/c-Met-TWIST1/2-VE-cadherin/VEGFR2 signaling axis[4]. The gene discussed is TWIST1; the disease is gastric cancer.