Comparison between the differentially expressed proteins from NPDR and PDR disease groups in different canonical pathways indicated increased LXR/RXR activation, FXR/RXR activation, acute phase response signaling, sucrose degradation V and regulation of actin-based motility by Rho in PDR disease group compared to NPDR disease group (Fig. 3). This evidence concerns the gene RHO and non-proliferative diabetic retinopathy.