Of the limited number of X-linked DMPs, we found an enrichment of DMPs associated to the microRNA MIR-223 and PABPC5. MIR-223 plays an important role in promoting granulocyte differentiation [39] whose deregulation is associated with various cancers [40–42] as well as endothelial cell apoptosis [43], implicating a putative role in the formation of ulcers in CD patients. This evidence concerns the gene PABPC5 and cancer.