TNFRSF11A and neoplasm: These authors established a mouse mammary tumour virus–RANK transgenic mice overexpressing the protein in mammary glands–and reported a high incidence of pre-neoplasia foci (multifocal ductal hyperplasias, multifocal and focally extensive mammary intraepithelial neoplasias), as well as the development of adenocarcinoma lesions in these transgenic mice compared with the wild-type mice.