β-catenin, c-myc and cyclin D1 mRNA expression in the OVX+E2 and OVX+PTH groups were higher than those in the OVX group, indicating that oestrogen and PTH could increase the Wnt/β-catenin pathway expression at the same time as when they relieve disc degeneration. Here, CCND1 is linked to intervertebral disk degenerative disorder.