The nuclear pore complex component NUP358, a cofactor for HIV-1 early infection steps, has a cyclophilin domain at its carboxy terminus; however, this domain does not efficiently interact with Cs, making it unlikely that NUP358 is involved in the Cs/SDZ-NIM811-mediated rescue of infectivity from IFN-α-induced blocks (51, 65). This evidence concerns the gene RANBP2 and infection.