Using atherosclerosis-prone Ldlr−/−; hApoB100+/+ mice that are severely dyslipidemic and predisposed to develop atherosclerosis by the age of 4 to 6 months58 even when fed regular chow diet48, 49, 50, we observed lymphatic dysfunction as early as 3-month-old mice, before any sign of lesion formation. Here, LDLR is linked to atherosclerosis.