Along the same path, Vuorio et al. published that lymphatic impairment worsened the atherosclerosis plaque formation in atherogenic LDLR−/−/ApoB100/100 mice crossed with transgenic mice having lymphatic localized insufficiency, and analyzed the effects of the absence of lymphatics on lipoprotein metabolism and atherosclerosis41. This evidence concerns the gene LDLR and atherosclerosis.