Results from present study demonstrate that glomerulosclerosis worsened, proteinuria progressed, ERPF, RBF further decreased and RVR, FENa, plasma creatinine and cystatin C level further increased while the kidney injury biomarkers such as Cys-c, NGAL and α-SMA expressions in left kidney tended to be higher in proportion to AV size. This evidence concerns the gene LCN2 and glomerulosclerosis.