Similar to observations with the microarrays (Fig. 3 and Supplementary Figure 7), we found that SLE patients with high chemokine scores had greater serum IgG reactivity to unmodified and dimethylated (K11Me2) forms of the H2B peptides, compared to patients with low chemokine scores (Fig. 5). Here, H2BC21 is linked to systemic lupus erythematosus.