Also, variants implicated in Mendelian cancer syndromes may not necessarily be coding, examples of which include mutations in the MLH1 5’UTR region associated with CRC [159, 160] and presumed enhancers that may affect the expression of EPCAM-MSH2 read-through transcripts associated with CRC in EPCAM deletion carriers [161]. This evidence concerns the gene EPCAM and colorectal carcinoma.