ESR1 and Familial prostate cancer: For example, HOTAIR and Neat1 have been reported to be induced by E2.31, 32 In this regard, HOTAIR carries multiple functional EREs in its promoter region; in particular two of them reveal very strong activity in response to E2 in breast cancer cells.32 On the other hand, ER-regulated Neat1 serves as a critical modulator in prostate cancer.31 Therefore, identification of BC200 as an ER target gene increases the repertoire of ER-regulated lncRNAs.