TRIM63 and Sepsis: Mysm1 suppresses IFN-I signaling trough inactivation of TRAF3/TRAF6 complexes to protect against sepsis.40 The present study revealed that Mysm1 is required for expression of IRF2 and IRF8 in preserving self-renewal of HSC23, 24, 25 and in governing lineage commitment of HSC.26, 27 IRF2 functions as a suppressor of IFN-I signaling by occupying the IRF consensus site on target genes and subsequently preventing DNA binding by IRF1,41 which has an important role in maintaining quiescent HSC pool.