Mysm1 suppresses IFN-I signaling trough inactivation of TRAF3/TRAF6 complexes to protect against sepsis.40 The present study revealed that Mysm1 is required for expression of IRF2 and IRF8 in preserving self-renewal of HSC23, 24, 25 and in governing lineage commitment of HSC.26, 27 IRF2 functions as a suppressor of IFN-I signaling by occupying the IRF consensus site on target genes and subsequently preventing DNA binding by IRF1,41 which has an important role in maintaining quiescent HSC pool. Here, IRF2 is linked to Sepsis.