For example, ROS mediated CHOP-mediated ER stress underlie human lung adenocarcinoma cells apoptosis induced by resveratrol and arsenic trioxide.36 Cigarette smoke inducted human bronchial epithelial cell apoptosis via ROS-dependent ER Stress and CHOP.37 NADPH oxidase-dependent production of ROS induced ER stress in neutrophil-like HL60 cells.38 This evidence concerns the gene DDIT3 and lung adenocarcinoma.