DJ-1(PARK7) is originally identified as a gene associated with autosomal early-onset Parkinson's disease.20 In the past two decades, some novel functions of DJ-1 had been elucidated linking this gene to cancer, antioxidative stress and metabolism.21, 22, 23 Furthermore, emerging evidence of DJ-1 in inflammation has also been reported. The gene discussed is PARK7; the disease is Onset.