Using a similar model, it has been reported that Apc deletion by Lgr5-Cre rapidly induces tumor formation.6 In previous studies using the villin-Cre model, gastric tumors were detected at age 35–80 weeks,11 indicating that long-term KLF4 deletion could induce gastric tumors, probably by enhancing other oncogenic pathways. This evidence concerns the gene LGR5 and gastric neoplasm.