MALAT1 and colorectal cancer: TGF-β is a well-known EMT initiator.31 Lnc-ATB (lncRNA activated by TGF-β) is a TGF-β-induced lncRNA that could mediate TGF-β-induced EMT and has been shown to promote metastasis in hepatocellular carcinoma, colorectal cancer, gastric cancer, and breast cancer.32, 33, 34, 35, 36, 37 In addition, Fan and colleagues showed that TGF-β induced a specific lncRNA called metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which leads to EMT in bladder cancer cells.