Binding of small molecules may also induce conformational changes within lncRNA molecules and disrupt formation of important lncRNA structures.98 For instance, the interaction of HOTAIR with PRC2 or LSD1 can be inhibited with the help of HOTAIR-targeting small molecular inhibitors to reduce the metastasis in breast cancer.99 Overall, the development of new technologies to more efficient delivery of lncRNA-targeted therapeutics will help to bring lncRNA-based therapies closer to the clinic. The gene discussed is HOTAIR; the disease is breast cancer.