SUZ12 and neoplasm: Interestingly, MALAT1 is associated with the suppression of SUZ12, which prevents the ability of Snail1 from downregulating E-cadherin.38 Thus, the induction of MALAT1 by TGF-β results in decreased E-cadherin and increased N-cadherin/fibronectin, leading to enhanced EMT.38 Cancer-associated fibroblasts (CAFs) as one of the principal constituents of tumor stroma have an important role in tumor development.