The oncofetal H19 lncRNA is concomitantly induced by both TGF-β and hypoxia in a mouse breast cancer model, which regulates E-cadherin expression and stimulates tumor metastasis through a positive feedback loop between Slug and H19/miR-675.41 The positive regulation of H19 by HIF-1α may partially explain its high expression in metastases.42 Linc-RoR (regulator of reprogramming) is a hypoxia-responsive lncRNA that modulates expression of miR-145 and HIF-1α and acts through a hypoxia/miR-145/HIF-1α signaling axis to modulate EMT in vitro and in vivo.43 This evidence concerns the gene CDH1 and breast cancer.