HIF1A and breast cancer: Linc-ROR modulates hypoxia signaling through a miR-145/HIF-1α signaling pathway in HCC cells.43 Similarly, linc-ROR regulates EMT by acting as a sponge for miR-205, and linc-ROR overexpression prevents the degradation of miR-205 target genes in breast cancer cells, including the EMT inducer ZEB2.76 In summary, miRNAs and lncRNAs can cooperate with each other in an lncRNA-miRNA functional network to regulate EMT.77