RNASE3 and infection: On its turn, RNase 3, another of the main antimicrobial RNases within the RNase A superfamily (Fig. 1), also called the Eosinophil Cationic Protein (ECP), is involved in inflammatory processes mediated by eosinophils and is released by the secondary granules upon infection (Acharya and Ackerman 2014).